ZJU scientists unveil the enigma of the vulnerability of Achilles tendon
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2022-01-17
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In the human body, there is a soft spot- Achilles tendon. As its name suggests, the Achilles tendon is one of the most powerful and fragile tendons in the body. The Achilles tendon can endure a load close to 8 times the body weight during exercise, making it extremely vulnerable to injury. Furthermore, due to the unique nature of tendons, failing to consult a doctor soon after an injury can lead to chronic tendon disease, which is characterized by pain, swelling, and movement problems. Tendo het...
Scientists discover Cytochrome P450 family member CYP39A1 can block hepatocarcinogenesis
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2022-01-14
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Hepatocellular carcinoma (HCC) is two to five times more common in men than in women. An in-depth analysis of the mechanisms underlying the gender heterogeneity of HCC may contribute to the identification of key HCC suppression mechanisms physiologically present in women, thus benefiting the HCC cohort.A cytochrome P450 family member with female-preferential expression blocking hepatocarcinogenesisAgainst this backdrop, Prof. JI Junfang at the Zhejiang University Life Sciences Institute&nbs...
Light-controlled “drug-free” macromolecules for precise tumor therapy
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2022-01-07
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Drug-free macromolecular therapies can induce cell apoptosis by clustering non-internalizing cell-surface receptors. These show enormous promise in tumor treatment, particularly in terms of non-specific toxicities when compared with low-molecular-weight drugs. However, most reported drug-free macromolecular therapies involve a ‘two-step’ administration manner and there is a paucity of in vivo research. On December 23, 2021, the research team led by Prof. DU Yongzhong at the Coll...
New insights into asthma drug development
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2022-01-06
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Asthma is one of the most common chronic respiratory diseases worldwide and its prevalence is on the rise. Epidemiological studies reveal that the incidence of asthma ranges from 1% to 18% in various countries. More than 400 million people are suffering from asthma all over the world. The number of asthma patients aged 20 years and above in China has added up to 45.7 million. However, the treatment of asthma is far from satisfactory. Therefore, it is of urgent need to explore the pathogenesis of...
ZJU scientists reveal the genetic basis of mitochondrial diseases
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2021-12-31
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Mutations in genes encoding mitochondrial aminoacyl-tRNA synthetases are linked to diverse diseases. However, the precise mechanisms by which these mutations affect mitochondrial function and disease development are not fully understood.The joint team led by Dr. GE Wanzhong from the Women’s Hospital, Zhejiang University School of Medicine and Prof. GUAN Min-Xin from the Institute of Genetics, Zhejiang University published their collaborative research regarding the developmental delay ...
An exploration for lung cancer diagnosis and treatment
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2021-12-10
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Lung cancer is one of the leading cancer types for human mortality. Even though different medical interventions, such as chemotherapy, radiotherapy and immunotherapy, have contributed to lung cancer treatment in a great deal, the lack of an early diagnosis leads to poor prognosis and low overall survival rate. Less than 20% of patients survive to 5 years after diagnosis. Standard lung cancer screening methods employing computerized tomography (CT) examination encounter the challenge of distingui...
A novel “biological missile” targeting malignant tumor
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2021-10-04
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The team led by Prof. CHEN Shuqing and Prof. PAN Liqiang at the Zhejiang University College of Pharmaceutical Sciences published their latest research findings regarding a multivalent biparatopic EGFR-targeting nanobody drug conjugate in the journal Signal Transduction and Targeted Therapy on September 3. Design of multivalent anti-EGFR nanobody drug conjugateAn antibody-drug conjugate (ADC) is a type of anticancer drug linking an antibody with cytotoxic molecules. It integra...
Novel therapeutics against obesity by activating melanocortin-4 receptor
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2021-10-02
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Satiety in the gut is regulated by the nervous system. The melanocortin-4 receptor (MC4R) in the hypothalamus is known as the brain’s “switchboard” to control appetite and metabolism. It is a popular target for the treatment of such metabolic diseases as obesity by regulating the body’s energy metabolism and eating behavior in response to the simulation of proopiomelanocortin (POMC) and agouti-related peptide (AgRP) by various metabolic signals such as leptin and neuropeptide Y. MC4R belongs...
ZJU4H becomes Zhejiang’s first Grade V Level B hospital in connectivity
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2021-07-18
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At the 16th China Health Information Technology/ Healthcare Big Data Application Exchange Conference held on July 10, the Fourth Affiliated Hospital of the Zhejiang University School of Medicine (ZJU4H) was rated as a Grade V Level B hospital in China Health Information Connectivity Standardization Maturity Assessment, which is the highest level in this regard in China.In May, the assessment panel conducted an on-site inspection of ZJU4H and lauded its remarkable information infrastruc...
ZJU oncologists characterize a genomic landscape of alpha-fetoprotein producing gastric cancer
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2021-07-07
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Being the fifth morbidity and the third leading cause of tumor mortality worldwide, gastric cancer (GC) remains to be a major health burden. Although alpha-fetoprotein (AFP) has been widely applied as a relatively specific marker for liver cancer, some other tumors such as a subgroup of gastric cancer can also produce and secrete AFP, namely AFP producing gastric cancer (AFPGC). AFPGC is a special and rare subtype of gastric cancer, accounting for 1.3-5.4% of GC. Compared with common GC, patient...