SAHZU Performs China’s First 5G-Assisted Remote Intracerebral Hematoma Aspiration
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2021-06-22
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On June 17, Prof. LIU Fengqiang, a neurosurgeon from the Second Affiliated Hospital Zhejiang University School of Medicine (SAHZU),remotely manipulated Remebot, a stereotactic neurosurgery robot, through a 5G network to evacuate the intracerebral hematoma of a patient, who was located 200 kilometers away in Songyang Hospital of Li Shui City. This marked the successful establishment of China’s first 5G-based digital neurosurgery operating theater.During the surgery, the scene of the operat...
Response mechanism of ICB among patients with breast cancer and novel approach to predicting therapeutic efficacy
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2377030
/english/2021/0522/c65147a2377030/page.psp
2021-05-22
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Immunotherapeutic drugs, as represented by immune-checkpoint blockade (ICB), have achieved tremendous success in curing various tumors in recent years, thus improving the survival and life quality of some tumor patients in an appreciable manner. Recent data from clinical trials on breast cancer patients suggest that ICB, in combination with neo-adjuvant chemotherapy, can improve the pathological complete response (pCR) rate and the event-free survival rate in breast cancer. Neo-adjuvant ICB is e...
Scientists discover novel metabolic mechanisms of targeted therapy resistance in liver cancer
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2021-05-22
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Liver cancer is the fourth leading cause of cancer-related death globally. It is indeed the second most lethal tumor. Hepatocellular carcinoma (HCC) is the major type among them. Recently, it was noticed that metabolic dysregulation contributed a lot to the progression of HCC, whereas the roles of metabolic dysregulation in HCC treatment has not been fully revealed. Sorafenib has been a standard targeted therapy for advanced HCC, where metabolic aspect especially ROS is deeply involved. Sorafeni...
A patch for activation of anticancer drug inside tumor
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/english/2021/0510/c65147a2359765/page.psp
2021-05-11
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Pharmaceutical researchers have developed a new technique that uses a patch with microneedles to perform catalyzed reactions for generating anticancer therapeutics directly inside tumors. Early laboratory tests on mice show it potentiates the effectiveness of drugs and reduces toxicity. The technique was developed by researchers at Zhejiang University, Fuzhou University and the University of California, Los Angeles.“This is a proof of concept, but we’ve demonstrated there is now a new tool for...
Scientists reveal blurry perception and the brain’s molecular mechanism in major depressive disorder
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/english/2021/0511/c65147a2359894/page.psp
2021-05-11
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Depression is commonly associated with cognitive deficits in memory and emotions like sadness. This association alone, however, neglects the intense difference in how subjects perceive others and the world in this mental state. Depressed subjects often perceive their environment in an unsharp and blurry way. That, in turn, affects our emotion, cognition and behavior since we act and think according to the way we perceive. The research teams of SONG Xuemei at the Zhejiang University School of Med...
New mechanism of cancer escape from immunity via EGFR-GSK3α-ARIH1 signaling
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/english/2021/0506/c65147a2353562/page.psp
2021-05-07
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Tumor is one of the major hazards for human health and life. With the cross-disciplinary fusion of immunology and cell biology, tumor immunotherapy technology has become an important means of anti-tumor treatment.Programmed death ligand-1 (PD-L1) is constitutively expressed on the surface of cancer cells. The interaction between PD-L1 and its receptor, programmed death protein-1 (PD-1), which is mainly expressed on the surface of T cells, results in cancer cell evasion from immune surveillance. ...
Novel photosensitization technology for deep-tumor photodynamic therapy
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/english/2021/0506/c65147a2351844/page.psp
2021-05-05
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Photosensitization reactions for the generation of reactive oxygen species (ROS) play crucial roles in many applications, including energy conversion, organic waste decomposition, and photodynamic therapy (PDT). Using near-infrared (NIR) light for photosensitization is attractive because NIR excitation offers deeper penetration through various media such as wastewater and biological tissues. However, conventional approaches for NIR photosensitization are hampered by low conversion efficiency and...
New approach to treating Alzheimer’s disease
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/english/2021/0423/c65147a2316777/page.psp
2021-04-23
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Alzheimer’s disease (AD) is the most common type of dementia. It is a progressive disease beginning with mild memory loss and possibly leading to loss of the ability to carry on a conversation and respond to the environment. It involves parts of the brain that control thought, memory, and language and can seriously affect a person’s ability to carry out daily activities. AD has become an increasingly severe public health and social problem. According to the Alzheimer’s Association, one patien...
ZJU scientists unravel the mystery of anger and aggression
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/english/2021/0423/c65147a2316916/page.psp
2021-04-21
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When we are provoked or threatened, anger often arises and it is even accompanied by certain aggressive behaviors. In the biological chain, stalking and hunting are quite common in the natural world. Aggression is a core strategy in the law of survival of the fittest. Most animals have evolved specific neural circuits to regulate aggressive behavior. Then how do brain circuits manage anger and govern aggression?The armed forces in the brainThe research team led by academician DUAN Shumin an...
Dissolvable microneedle patch for treatment of inflammatory skin disorders
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2021-04-16
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The research team led by Prof. PING Yuan from the Zhejiang University College of Pharmaceutical Sciences published their study in the journal Science Advances. They developed a dissolvable microneedle (MN) patch that can mediate transdermal co-delivery of CRISPR-Cas9–based genome-editing agents and glucocorticoids for the effective treatment of inflammatory skin disorders (ISDs).ISDs represent one of the most persistent diseases that are generally characterized by the activation o...